4 edition of The argininosuccinate lyase gene of Campylobacter jejuni found in the catalog.
The argininosuccinate lyase gene of Campylobacter jejuni
by National Library of Canada = Bibliothèque nationale du Canada in Ottawa
Written in English
|Series||Canadian theses = Thèses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative.|
Campylobacter jejuni is a microaerophilic pathogen representing one of the major causes of bacterial enteritis in humans. The oxidative stress response after exposure to paraquat, a strong oxidising agent, was analysed by two-dimensional protein electrophoresis and Maldi-ToF mass by: Cloning, characterization, and nucleotide sequence analysis of the argH gene from Campylobacter jejuni TGH encoding argininosuccinate lyase. Hani EK, Chan VL J Bacteriol, (7), 01 Apr Cited by:
A complete isoleucyl-tRNA synthetase gene (ileS) of Campylobacter jejuni was isolated from a C. jejuni TGH genomic DNA library constructed in pBluescript. In argininosuccinic aciduria, the enzyme argininosuccinate lyase, involved in the conversion of arginino succinate to arginine within the urea cycle, is damaged or missing. The urea cycle cannot proceed normally, and nitrogen accumulates in the bloodstream in the form of lty: Endocrinology.
Arginosuccinate lyase deficiency deficiency was first described in by the British doctor JD Allan and his nosuccinate lyase deficiency is an inherited, congenital metabolic disease caused by a defect in the urea cycle. In this cycle a chain of enzymes in the liver converts ammonia into urea. Campylobacter is the leading cause of foodborne diarrhoeal illness in humans and is mostly acquired from consumption or handling of contaminated poultry meat. In the absence of effective licensed vaccines and inhibitors, selection for chickens with increased resistance to Campylobacter could potentially reduce its subsequent entry into the food chain.
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Hani EK, Chan VL. Cloning, characterization, and nucleotide sequence analysis of the argH gene from Campylobacter jejuni TGH encoding argininosuccinate lyase. J Bacteriol. Apr; (7)– [PMC free article] Harvey SM.
Hippurate hydrolysis by Campylobacter fetus. J Clin Microbiol. Apr; 11 (4)– [PMC free article]Cited by: Argininosuccinate lyase (argH) This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
Argininosuccinate lyase is a cytosolic homotetramer of kd. It catalyzes the cleavage of argininosuccinic acid to arginine and fumarate, an essential step in urea production. ASL is the only enzyme in the body that is capable of generating arginine. Abnormal gene by: The complete structural gene for argininosuccinate lyase (argH) from Campylobacter jejuni TGH has been cloned into Escherichia coli by complementation of an E.
coli argH auxotrophic mutant. The gene has been subcloned for sequencing on a kb DNA segment and localized by the complementing activity of deletion by: UniProtKB. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC / NCTC ) Status. Argininosuccinate synthase (argG) Argininosuccinate lyase Gene names i: Name:argG UniRule annotation Ordered Locus Names: Cjc.
Organism i: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC / NCTC ) Taxonomic. The complete structural gene for argininosuccinate lyase (argH) from Campylobacter jejuni TGH has been cloned into Escherichia coli by complementation of an E.
coli The argininosuccinate lyase gene of Campylobacter jejuni book. Hani EK, Chan VL. Cloning, characterization, and nucleotide sequence analysis of the argH gene from Campylobacter jejuni TGH encoding argininosuccinate lyase. J Bacteriol. Apr; (7)– [Europe PMC free article] [Google Scholar] Harvey SM.
Hippurate hydrolysis by Campylobacter fetus. J Clin Microbiol. Apr; 11 (4) Cited by: Information on EC - argininosuccinate lyase for references in articles please use BRENDA:EC Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree 4 Lyases Carbon-nitrogen lyases Amidine-lyases argininosuccinate lyase. Abstract. The genomic map of Campylobacter jejuni UA was expanded and more precisely constructed using I-CeuI, SalI and SmaI restriction endonucleases in coCited by: The complete structural gene for argininosuccinate lyase (argH) from Campylobacterjejuni TGH has beenclonedintoEscherichiacoli bycomplementation argHauxotrophic ehasbeen subcloned for sequencing on a kb DNAsegment and localized by the complementing activity ofdeletionCited by: The genome sequence of C.
jejuni was produced in collaboration with Brendan Wren of the London School of Hygiene and Tropical Medicine and Dr. Julian Ketley of the Department of Genetics, University of Leicester.
It was sequenced using a whole genome shotgun approach using several kb pUC18 libraries, both generated in-house, and supplied by Andrey V. Karlyshev from Dr. Wren's laboratory.
Pathogenic variants in the argininosuccinate lyase (ASL) gene have been shown to cause argininosuccinate lyase deficiency (ASLD); therefore, sequencing.
Since the publication of the complete genomic sequence of C. jejuni NCTC in Februaryevidence that Campylobacter jejuni strains exhibit high genomic sequence diversity has been accumulating ().This genetic variability was demonstrated with a battery of different technologies, including microarray-based genotyping (9, 27, 35), multiple locus sequence typing (), restriction Cited by: Recombinant plasmids containing the argH gene generate a kDa protein and a kDa protein in E.
coli maxicells. The C. jejuni argH gene shows nucleotide homology to both yeast and human argininosuccinate lyase genes, and conserved amino acid domains are evident between the corresponding proteins.
Argininosuccinate Lyase (ASL) Consisting of 16 exons, the ASL gene is located at position 7q, and encodes for the monomer subunit of argininosuccinate lyase.
Four identical ASL monomers assemble to form a functional homotetramer of kDa, which is able to breakdown argininosuccinate to yield arginine and fumarate. Argininosuccinate lyase (ASL) This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine and fumarate from (N(omega)-L-arginino)succinate, the pathway urea cycle and in Nitrogen metabolism. Linnebank M, Tschiedel E, Häberle J, et al. Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL gene.
The genomic map of Campylobacter jejuni UA was expanded and more precisely constructed using I-CeuI, SalI and SmaI restriction endonucleases in conjunction with pulsed-field gel electrophoresis (PFGE).The presence of three fragments after digestion with I-CeuI confirmed the presence of three copies of the 23S ribosomal rRNA (rrl) genome size of Campylobacter jejuni UA was Cited by: Campylobacter jejuni is the leading cause of bacterial food borne illness.
While helical cell shape is considered important for C. jejuni pathogenesis, this bacterium is capable of adopting other morphologies. To better understand how helical-shaped C. jejuni maintain their shape and thus any associated colonisation, pathogenicity or other advantage, it is first important to identify the genes Cited by: 4.
Campylobacter jejuni is considered as the leading cause of gastroenteritis all over the world. This bacterium has the CRISPR–cas9 system, which is used as a gene editing technique in different organisms. However, its role in bacterial virulence has just been discovered; that discovery, however, is just the tip of the iceberg.
The purpose of this study is to find out the relationship between Cited by: 5. The gene for ASA lyase deficiency is located on chromosome 7 and has been mapped to the locus 7q The normal gene has been cloned and comprises approximately 35 kilobases and 16 exons.
Approximately mutational variants have been reported, most of which are private and vary widely in nature, from missense to deletions.ASL, argininosuccinate lyase; GRP78, 78 kDa glucose-regulated protein.
ASL shRNA inhibits cell growth in colorectal cancer To study the function of ASL in colorectal cancer, HCT cells were transfected with ASL-targeting shRNA, and the stable transfectant cells Cited by: 8.